Limited brain metastases: a narrative review
نویسندگان
چکیده
: Limited brain metastases refer to an oligometastatic state in the for which focal therapy with stereotactic radiosurgery (SRS) is appropriate. The definition of what considered “limited” metastases, however, not well defined. Multiple recent randomized trials show that metastasis-directed surgery or radiation can prolong survival patients 1–5 from various primary tumors, but untreated were largely excluded these trials. Stereotactic allows treatment multiple while avoiding whole (WBRT), has a known negative impact on neurocognitive function. Randomized have shown alone effective up 4 decreased side effects and no detriment overall (OS). These data led our current metastases. However, more suggests 10 benefit SRS. Ongoing are investigating if 15–20 may similarly SRS alone. Advances systemic therapies penetrate blood-brain barrier greater activity central nervous system (CNS) also expand population whom appropriate treatment. Immunotherapy be synergistic some cases. This narrative review will discuss evolving management limited
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ژورنال
عنوان ژورنال: Annals of palliative medicine
سال: 2021
ISSN: ['2224-5839', '2224-5820']
DOI: https://doi.org/10.21037/apm-21-363